Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.

Thrombin is a serine protease that plays a central role in blood coagulation. It is inhibited by hirudin, a polypeptide of 65 amino acids, through the formation of a tight, noncovalent complex. Tetragonal crystals of the complex formed between human alpha-thrombin and recombinant hirudin (variant 1)...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Grütter, M G, Priestle, J P, Rahuel, J, Grossenbacher, H, Bode, W, Hofsteenge, J, Stone, S R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2369893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb07410.x
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