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Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.

Thrombin is a serine protease that plays a central role in blood coagulation. It is inhibited by hirudin, a polypeptide of 65 amino acids, through the formation of a tight, noncovalent complex. Tetragonal crystals of the complex formed between human alpha-thrombin and recombinant hirudin (variant 1)...

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Bibliografiske detaljer
Main Authors: Grütter, M G, Priestle, J P, Rahuel, J, Grossenbacher, H, Bode, W, Hofsteenge, J, Stone, S R
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC552259/
https://ncbi.nlm.nih.gov/pubmed/2369893
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