The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers

The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both neurotoxic. Therefore, one of the main therapeutic approaches to cure or d...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Valls-Comamala, Victòria, Guivernau, Biuse, Bonet, Jaume, Puig, Marta, Perálvarez-Marín, Alex, Palomer, Ernest, Fernàndez-Busquets, Xavier, Altafaj, Xavier, Tajes, Marta, Puig-Pijoan, Albert, Vicente, Rubén, Oliva, Baldomero, Muñoz, Francisco J.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522293/
https://ncbi.nlm.nih.gov/pubmed/28467807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17074
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