Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy

GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which encodes a key enzyme in sialic acid biosynthe...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bosch-Morató, Mònica, Iriondo, Cinta, Guivernau, Biuse, Valls-Comamala, Victòria, Vidal, Noemí, Olivé, Montse, Querfurth, Henry, Muñoz, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924647/
https://ncbi.nlm.nih.gov/pubmed/26968811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7997
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