Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy

GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which encodes a key enzyme in sialic acid biosynthe...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Bosch-Morató, Mònica, Iriondo, Cinta, Guivernau, Biuse, Valls-Comamala, Victòria, Vidal, Noemí, Olivé, Montse, Querfurth, Henry, Muñoz, Francisco J.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper: Gerotarget (Focus on Aging)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924647/
https://ncbi.nlm.nih.gov/pubmed/26968811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7997
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