Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners

Excessive and prolonged activation of macrophages underlies many inflammatory and autoimmune diseases. To regulate activation and maintain homeostasis, macrophages have multiple intrinsic mechanisms, one of which is modulation through autophagy. Here we demonstrate that autophagy induction by rapamy...

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Vydáno v:Oncotarget
Hlavní autoři: Ko, Jung Hwa, Yoon, Sun-Ok, Lee, Hyun Ju, Oh, Joo Youn
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522223/
https://ncbi.nlm.nih.gov/pubmed/28489580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17256
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