Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

When BHK21 cells synchronized in early S phase were exposed to okadaic acid (OA), an inhibitor of protein phosphatases 1 and 2A, mitosis specific events such as premature chromosome condensation, the production of MPM-2 antigens, dispersion of nuclear lamins and the appearance of mitotic asters were...

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Detalhes bibliográficos
Main Authors: Yamashita, K, Yasuda, H, Pines, J, Yasumoto, K, Nishitani, H, Ohtsubo, M, Hunter, T, Sugimura, T, Nishimoto, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC552219/
https://ncbi.nlm.nih.gov/pubmed/2176149
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