Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

Lignende værker

• Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.
  af: Nishitani, H, et al.
  Udgivet: (1991)
• A Dual-Specificity Phosphatase Cdc25B Is an Unstable Protein and Triggers p34(cdc2)/Cyclin B Activation in Hamster BHK21 Cells Arrested with Hydroxyurea
  af: Nishijima, Hitoshi, et al.
  Udgivet: (1997)
• Affinity of okadaic acid to type-1 and type-2A protein phosphatases is markedly reduced by oxidation of its 27-hydroxyl group.
  af: Sasaki, K, et al.
  Udgivet: (1994)
• Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene.
  af: Uchida, S, et al.
  Udgivet: (1990)
• Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.
  af: Seki, T, et al.
  Udgivet: (1992)