Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

Novel targeted and immunotherapeutic approaches have revolutionized the treatment of metastatic melanoma. A better understanding of the melanoma-microenvironment, in particular the interaction of cells with extracellular matrix molecules, may help to further improve these new therapeutic strategies....

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Publicado en:Oncotarget
Main Authors: Andrlová, Hana, Mastroianni, Justin, Madl, Josef, Kern, Johannes S., Melchinger, Wolfgang, Dierbach, Heide, Wernet, Florian, Follo, Marie, Technau-Hafsi, Kristin, Has, Cristina, Mittapalli, Venugopal Rao, Idzko, Marco, Herr, Ricarda, Brummer, Tilman, Ungefroren, Hendrik, Busch, Hauke, Boerries, Melanie, Narr, Andreas, Ihorst, Gabriele, Vennin, Claire, Schmitt-Graeff, Annette, Minguet, Susana, Timpson, Paul, Duyster, Justus, Meiss, Frank, Römer, Winfried, Zeiser, Robert
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522114/
https://ncbi.nlm.nih.gov/pubmed/28476030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17160
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