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Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB
The programmed death-ligand 1 (PD-L1), by binding to PD-1 on the surface of immune cells, activates a major immune checkpoint pathway. Elevated expression of PD-L1 in tumor cells mediates tumor-induced T-cell exhaustion and immune suppression; therefore protect the survival of tumor cells. Although...
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| Опубликовано в: : | Oncotarget |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Impact Journals LLC
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522076/ https://ncbi.nlm.nih.gov/pubmed/28465490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17123 |
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