Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB

The programmed death-ligand 1 (PD-L1), by binding to PD-1 on the surface of immune cells, activates a major immune checkpoint pathway. Elevated expression of PD-L1 in tumor cells mediates tumor-induced T-cell exhaustion and immune suppression; therefore protect the survival of tumor cells. Although...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Xue, Junli, Chen, Chunhua, Qi, Manlong, Huang, Yan, Wang, Lin, Gao, Yong, Dong, Haidong, Ling, Kun
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522076/
https://ncbi.nlm.nih.gov/pubmed/28465490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17123
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