Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia

Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2α, in the hypoxia signaling pathway. Variation...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Bi, Jianling, Hu, Bo, Wang, Jing, Liu, Xing, Zheng, Jinsong, Wang, Ding, Xiao, Wuhan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522066/
https://ncbi.nlm.nih.gov/pubmed/28178687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15038
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