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Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition

Modulation of the immune system for the treatment of primary and metastatic tumors has been a goal of cancer research for many years. The E3 ubiquitin ligase Cbl-b has been established as an intracellular checkpoint that limits T cell activation, critically contributing to the maintenance of self-to...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Peer, Sebastian, Baier, Gottfried, Gruber, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522032/
https://ncbi.nlm.nih.gov/pubmed/28611299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18360
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