STAT1 deficiency supports PD-1/PD-L1 signaling resulting in dysfunctional TNFα mediated immune responses in a model of NSCLC

In this study we described that Signal Transducer and Activator of Transcription 1 (STAT1) is a key point regulator of PD-1 in tumour infiltrating lymphocytes and PD-L1 in Tumour associated macrophages (TAM) in NSCLC. In our murine model of adenocarcinoma targeted deletion of Stat1 was found associa...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Friedrich, Juliane, Heim, Lisanne, Trufa, Denis I., Sirbu, Horia, Rieker, Ralf J., Chiriac, Mircea T., Finotto, Susetta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324686/
https://ncbi.nlm.nih.gov/pubmed/30647851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26441
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