Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma

BACKGROUND: In spite of modern therapies for non-small-cell lung cancer (NSCLC), prognosis for many patients is still poor and survival rates are low. Immunotherapy is the possibility to improve the lung immune response surrounding the tumour. However, this approach requires detailed understanding o...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Andreev, Katerina, Denis Iulian Trufa, I, Siegemund, Raphaela, Rieker, Ralf, Hartmann, Arndt, Schmidt, Joachim, Sirbu, Horia, Finotto, Susetta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578079/
https://ncbi.nlm.nih.gov/pubmed/26348446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.255
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