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Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

RU486 induced the binding to a palindromic progestin responsive element (PRE) in vitro of homo- and heterodimers of the human progesterone receptor (hPR) isoforms A and B, present in T47D breast cancer cells or in HeLa cells transiently expressing the recombinant proteins. The resulting complexes we...

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Main Authors: Meyer, M E, Pornon, A, Ji, J W, Bocquel, M T, Chambon, P, Gronemeyer, H
Formato: Artigo
Idioma:Inglês
Publicado: 1990
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC552163/
https://ncbi.nlm.nih.gov/pubmed/2249658
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