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The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein

The extracellular adherence protein (Eap) plays a crucial role in pathogenesis and survival of Staphylococcus aureus by inhibiting the classical and lectin pathways of complement. We have previously shown that Eap binds with nanomolar affinity to complement C4b and disrupts the initial interaction b...

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Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Woehl, Jordan L., Ramyar, Kasra X., Katz, Benjamin B., Walker, John K., Geisbrecht, Brian V.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521547/
https://ncbi.nlm.nih.gov/pubmed/28512867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3195
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