Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

The human complement system plays an essential role in innate and adaptive immunity by marking and eliminating microbial intruders. Activation of complement on foreign surfaces results in proteolytic cleavage of complement component 3 (C3) into the potent opsonin C3b, which triggers a variety of imm...

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Main Authors: Garcia, Brandon L., Ramyar, Kasra X., Tzekou, Apostolia, Ricklin, Daniel, McWhorter, William J., Lambris, John D., Geisbrecht, Brian V.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930029/
https://ncbi.nlm.nih.gov/pubmed/20654625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.07.029
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