A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins

Complement is a network of interacting circulatory and cell surface proteins that recognizes, marks, and facilitates clearance of microbial invaders. To evade complement attack, the pathogenic organism Staphylococcus aureus expresses a number of secreted proteins that interfere with activation and r...

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Bibliographic Details
Main Authors: Garcia, Brandon L., Summers, Brady J., Ramyar, Kasra X., Tzekou, Apostolia, Lin, Zhuoer, Ricklin, Daniel, Lambris, John D., Laity, John H., Geisbrecht, Brian V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554951/
https://ncbi.nlm.nih.gov/pubmed/23233676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426858
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