Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy

Overcoming metabolic stress is a critical step in tumor growth. Acetyl-CoA generated from glucose and acetate uptake is important for histone acetylation and gene expression. However, how acetyl-CoA is produced under nutritional stress is unclear. We demonstrate here that glucose deprivation results...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Li, Xinjian, Yu, Willie, Qian, Xu, Xia, Yan, Zheng, Yanhua, Lee, Jong-Ho, Li, Wei, Lyu, Jianxin, Rao, Ganesh, Zhang, Xiaochun, Qian, Chao-Nan, Rozen, Steven G, Jiang, Tao, Lu, Zhimin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521213/
https://ncbi.nlm.nih.gov/pubmed/28552616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.026
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