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A gradient of sitewise diversity promotes evolutionary fitness for binder discovery in a three-helix bundle protein scaffold
Engineered proteins provide clinically and industrially impactful molecules and utility within fundamental research. Yet, inefficiencies in discovering lead variants with new desired function, while maintaining stability, hinder progress. Improved function, which can result from a few strategic muta...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5521020/ https://ncbi.nlm.nih.gov/pubmed/28248518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01142 |
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