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Upregulation of the ATR-CHEK1 Pathway in Oral Squamous Cell Carcinomas
The ATR-CHEK1 pathway is upregulated and overactivated in Ataxia Telangiectasia (AT) cells, which lack functional ATM protein. Loss of ATM in AT confers radiosensitivity, although ATR-CHEK1 pathway overactivation compensates, leads to prolonged G(2) arrest after treatment with ionizing radiation (IR...
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| Publicado no: | Genes Chromosomes Cancer |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5520977/ https://ncbi.nlm.nih.gov/pubmed/24142626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22115 |
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