Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons

Autophagy is triggered during nutrient and energy deprivation in a variety of cells as a homeostatic response to metabolic stress. In the CNS, deficient autophagy has been implicated in neurodegenerative diseases and ischemic brain injury. However, its role in hypoglycemic damage is poorly understoo...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Gerónimo-Olvera, Cristian, Montiel, Teresa, Rincon-Heredia, Ruth, Castro-Obregón, Susana, Massieu, Lourdes
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520945/
https://ncbi.nlm.nih.gov/pubmed/28661473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.299
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