Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis

Chemotherapy-induced thrombocytopenia is a common bleeding risk in cancer patients and limits chemotherapy dose and frequency. Recent data from mouse and human platelets revealed that activation of protein kinase A/G (PKA/PKG) not only inhibited thrombin/convulxin-induced platelet activation but als...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Rukoyatkina, Natalia, Butt, Elke, Subramanian, Hariharan, Nikolaev, Viacheslav O, Mindukshev, Igor, Walter, Ulrich, Gambaryan, Stepan, Benz, Peter M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520940/
https://ncbi.nlm.nih.gov/pubmed/28661475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.290
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