Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP. Male SHRSP, SHRSR, two reciprocal SHRSR/SHRSP-STR1/QTL stroke congenic lines received JD for 4...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Rubattu, Speranza, Stanzione, Rosita, Bianchi, Franca, Cotugno, Maria, Forte, Maurizio, Ragione, Floriana Della, Fioriniello, Salvatore, D'Esposito, Maurizio, Marchitti, Simona, Madonna, Michele, Baima, Simona, Morelli, Giorgio, Sciarretta, Sebastiano, Sironi, Luigi, Gelosa, Paolo, Volpe, Massimo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520932/
https://ncbi.nlm.nih.gov/pubmed/28640254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.278
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