Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains

OBJECTIVES: We examined expression protein of AMPK/SIRT1/PGC1α/PhoxO3a/PPARα/UCP2 pathway in brain, kidneys and heart of stroke-prone spontaneously hypertensive rat (SHRSP) vs stroke-resistant SHR (SHRSR) at different weeks of age, up to one year, in order to test the hypothesis that abnormalities w...

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Pubblicato in:Oncotarget
Autori principali: Rubattu, Speranza, Bianchi, Franca, Busceti, Carla Letizia, Cotugno, Maria, Stanzione, Rosita, Marchitti, Simona, Di Castro, Sara, Madonna, Michele, Nicoletti, Ferdinando, Volpe, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper: Gerotarget (Focus on Aging)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662457/
https://ncbi.nlm.nih.gov/pubmed/26023797
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