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Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease

Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable...

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Détails bibliographiques
Publié dans:Oxid Med Cell Longev
Auteurs principaux: Rubattu, Speranza, Stanzione, Rosita, Volpe, Massimo
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993945/
https://ncbi.nlm.nih.gov/pubmed/27594970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1067801
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