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HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination
Integrase inhibitors are a class of antiretroviral drugs used for the treatment of AIDS that target HIV integrase, an enzyme responsible for integration of viral cDNA into host genome. RAG1, a critical enzyme involved in V(D)J recombination exhibits structural similarity to HIV integrase. We find th...
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| 發表在: | Cell Death Dis |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5520896/ https://ncbi.nlm.nih.gov/pubmed/28569776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.237 |
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