RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion

The M2 isoform of pyruvate kinase (PKM2) is a key driver of glycolysis in cancer cells and has critical ‘non-metabolic’ functions in some cancers; however, the role of PKM2 in pancreatic cancer remains unclear. The aim of the current study was to elucidate the role of PKM2 in pancreatic cancer progr...

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Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Xu, Yanni, Chu, Liang, Yuan, Sujing, Yang, Yuanqin, Yang, Yu, Xu, Bin, Zhang, Kangjian, Liu, Xin-Yuan, Wang, Ruwei, Fang, Ling, Chen, Zhinan, Liang, Zongsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520890/
https://ncbi.nlm.nih.gov/pubmed/28569774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.230
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