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An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is characterized by alterations in multiple genes. High expression of CD147 on the surface of HCC cells promotes proliferation. The monoclonal antibody HAb18 recognizes CD147. We constructed an oncolytic adenoviral vector to express HAb18 (ZD55-HAb18) in HCC cells. Int...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yuan, Sujing, Fang, Xianlong, Xu, Yanni, Ni, Aimin, Liu, Xin-Yuan, Chu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312398/
https://ncbi.nlm.nih.gov/pubmed/27528029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11134
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