Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viabilit...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cheteh, Emarndeena H, Augsten, Martin, Rundqvist, Helene, Bianchi, Julie, Sarne, Victoria, Egevad, Lars, Bykov, Vladimir JN, Östman, Arne, Wiman, Klas G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520886/
https://ncbi.nlm.nih.gov/pubmed/28569790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.225
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