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Chimeric antigen receptors: driving immunology towards synthetic biology

The advent of second generation CARs and the CD19 paradigm have ushered a new therapeutic modality in oncology. In contrast to earlier forms of adoptive cell therapy, which were based on the isolation and expansion of naturally occurring T cells, CAR therapy is based on the design and manufacture of...

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Опубликовано в: :Curr Opin Immunol
Главный автор: Sadelain, Michel
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520666/
https://ncbi.nlm.nih.gov/pubmed/27372731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2016.06.004
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