A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium

The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it is a tumor promoter for cancerous cells. Such dichotomous actions are dictated...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Eritja, Nuria, Felip, Isidre, Dosil, Mari Alba, Vigezzi, Lucia, Mirantes, Cristina, Yeramian, Andree, Navaridas, Raúl, Santacana, Maria, Llobet-Navas, David, Yoshimura, Akihiko, Nomura, Masatoshi, Encinas, Mario, Matias-Guiu, Xavier, Dolcet, Xavi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520461/
https://ncbi.nlm.nih.gov/pubmed/28524854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.73
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