Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies

Since its discovery in the late 1990s, Pten has turned out to be one of the most important tumor suppressor genes. Pten loss results in increased activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, which is associated with increased proliferation, survival, and neoplastic growth....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Mirantes, Cristina, Dosil, Maria Alba, Hills, David, Yang, Jian, Eritja, Núria, Santacana, Maria, Gatius, Sònia, Vilardell, Felip, Medvinsky, Alexander, Matias-Guiu, Xavier, Dolcet, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874386/
https://ncbi.nlm.nih.gov/pubmed/26773036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-669036
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados