Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease

Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei was previously identified as a B-cell antigen. We tested the capacity of...

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Udgivet i:Infect Immun
Main Authors: Trotta, Lucia, Weigt, Kathleen, Schinnerling, Katina, Geelhaar-Karsch, Anika, Oelkers, Gerrit, Biagi, Federico, Corazza, Gino Roberto, Allers, Kristina, Schneider, Thomas, Erben, Ulrike, Moos, Verena
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520441/
https://ncbi.nlm.nih.gov/pubmed/28559404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00363-17
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