MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1

Frequent KRAS mutations contribute to multiple cancers including ~40% of human colorectal cancers (CRCs). Systematic screening of 1255 microRNAs (miRNAs) identified miR-30a as a synthetic lethal in KRAS-mutant CRC cells. miR-30a was downregulated in CRCs and repressed by P65. miR-30a directly target...

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Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Shen, Hongxing, Xing, Chuan, Cui, Kaisa, Li, Yunxiao, Zhang, Jinxiang, Du, Runlei, Zhang, Xiaodong, Li, Youjun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520171/
https://ncbi.nlm.nih.gov/pubmed/28475173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.63
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