Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

The spatiotemporal organization of cytokine receptors in the plasma membrane is still debated with models ranging from ligand-independent receptor pre-dimerization to ligand-induced receptor dimerization occurring only after receptor uptake into endosomes. Here, we explore the molecular and cellular...

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Pubblicato in:Nat Commun
Autori principali: Richter, David, Moraga, Ignacio, Winkelmann, Hauke, Birkholz, Oliver, Wilmes, Stephan, Schulte, Markos, Kraich, Michael, Kenneweg, Hella, Beutel, Oliver, Selenschik, Philipp, Paterok, Dirk, Gavutis, Martynas, Schmidt, Thomas, Garcia, K. Christopher, Müller, Thomas D., Piehler, Jacob
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519985/
https://ncbi.nlm.nih.gov/pubmed/28706306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15976
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