Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc(Min/+) mouse model of intestinal tumorigenesis

Genetic deletion or pharmacological inhibition of cyclooxygenase (COX)-2 abrogates intestinal adenoma development at early stages of colorectal carcinogenesis. COX-2 is localised to stromal cells (predominantly macrophages) in human and mouse intestinal adenomas. Therefore, we tested the hypothesis...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hull, Mark A., Cuthbert, Richard J., Ko, C. W. Stanley, Scott, Daniel J., Cartwright, Elizabeth J., Hawcroft, Gillian, Perry, Sarah L., Ingram, Nicola, Carr, Ian M., Markham, Alexander F., Bonifer, Constanze, Coletta, P. Louise
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519705/
https://ncbi.nlm.nih.gov/pubmed/28729694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06253-5
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker