Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc(Min/+) mouse model of intestinal tumorigenesis

Genetic deletion or pharmacological inhibition of cyclooxygenase (COX)-2 abrogates intestinal adenoma development at early stages of colorectal carcinogenesis. COX-2 is localised to stromal cells (predominantly macrophages) in human and mouse intestinal adenomas. Therefore, we tested the hypothesis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Hull, Mark A., Cuthbert, Richard J., Ko, C. W. Stanley, Scott, Daniel J., Cartwright, Elizabeth J., Hawcroft, Gillian, Perry, Sarah L., Ingram, Nicola, Carr, Ian M., Markham, Alexander F., Bonifer, Constanze, Coletta, P. Louise
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519705/
https://ncbi.nlm.nih.gov/pubmed/28729694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06253-5
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