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Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines

A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemic...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Yaghini, Elnaz, Dondi, Ruggero, Tewari, Kunal M., Loizidou, Marilena, Eggleston, Ian M., MacRobert, Alexander J.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519633/
https://ncbi.nlm.nih.gov/pubmed/28729656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06109-y
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