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Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines

A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemic...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Yaghini, Elnaz, Dondi, Ruggero, Tewari, Kunal M., Loizidou, Marilena, Eggleston, Ian M., MacRobert, Alexander J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519633/
https://ncbi.nlm.nih.gov/pubmed/28729656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06109-y
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