HLA mismatching favoring host-versus-graft NK cell activity via KIR3DL1 is associated with improved outcomes following lung transplantation

Chronic lung allograft dysfunction (CLAD) is linked to rejection and limits survival following lung transplantation. HLA-Bw4 recipients of HLA-Bw6 grafts have enhanced host-versus-graft (HVG) NK cell activity mediated by KIR3DL1 ligand. Because natural killer (NK) cells may promote tolerance by depl...

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Detalhes bibliográficos
Publicado no:Am J Transplant
Main Authors: Greenland, John R., Sun, Haibo, Calabrese, Daniel, Chong, Tiffany, Singer, Jonathan P., Kukreja, Jasleen, Hays, Steven R., Golden, Jeffrey A., Caughey, George H., Venstrom, Jeffrey M., Rajalinginam, Raja
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519429/
https://ncbi.nlm.nih.gov/pubmed/28375571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14295
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