Dynamic distinctions in the Na(+)/Ca(2+) exchanger adopting the inward- and outward-facing conformational states

Na(+)/Ca(2+) exchanger (NCX) proteins operate through the alternating access mechanism, where the ion-binding pocket is exposed in succession either to the extracellular or the intracellular face of the membrane. The archaeal NCX_Mj (Methanococcus jannaschii NCX) system was used to resolve the backb...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Giladi, Moshe, van Dijk, Liat, Refaeli, Bosmat, Almagor, Lior, Hiller, Reuben, Man, Petr, Forest, Eric, Khananshvili, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519378/
https://ncbi.nlm.nih.gov/pubmed/28572509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787168
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