Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause fetal damage and abortion in both animals and humans. Sphingolipids are essential and ubiquitous components of eukaryotic membranes that are both synthesized and scavenged by the Apicomplexa. He...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mina, John G., Thye, Julie K., Alqaisi, Amjed Q. I., Bird, Louise E., Dods, Robert H., Grøftehauge, Morten K., Mosely, Jackie A., Pratt, Steven, Shams-Eldin, Hosam, Schwarz, Ralph T., Pohl, Ehmke, Denny, Paul W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519370/
https://ncbi.nlm.nih.gov/pubmed/28578314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792374
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