Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes

G(i/o)-coupled G protein-coupled receptors can inhibit neurotransmitter release at synapses via multiple mechanisms. In addition to Gβγ-mediated modulation of voltage-gated calcium channels (VGCC), inhibition can also be mediated through the direct interaction of Gβγ subunits with the soluble N-ethy...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Zurawski, Zack, Page, Brian, Chicka, Michael C., Brindley, Rebecca L., Wells, Christopher A., Preininger, Anita M., Hyde, Karren, Gilbert, James A., Cruz-Rodriguez, Osvaldo, Currie, Kevin P. M., Chapman, Edwin R., Alford, Simon, Hamm, Heidi E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519367/
https://ncbi.nlm.nih.gov/pubmed/28515322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773523
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