A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.

To kill human or primate cells expressing the p55 subunit of the interleukin 2 receptor, we have constructed a single-chain immunotoxin. DNA sequences encoding the first 388 amino acids of diphtheria toxin (DT) were fused to DNA elements encoding the antigen-binding portion (variable region or Fv) o...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Chaudhary, V K, Gallo, M G, FitzGerald, D J, Pastan, I
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55192/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2251289/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9491
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