A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling

Here, by combining lipidomics with transcriptome analysis, we demonstrate that Rb depletion in mouse embryonic fibroblastss induces significant alterations in their lipid composition. We discovered that Rb depletion induced increase in lysophosphatidylserine, diacylglycerol (DAG), fatty acid (FA), a...

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Dettagli Bibliografici
Pubblicato in:Oncogenesis
Autori principali: Muranaka, H, Hayashi, A, Minami, K, Kitajima, S, Kohno, S, Nishimoto, Y, Nagatani, N, Suzuki, M, Kulathunga, L A N, Sasaki, N, Okada, N, Matsuzaka, T, Shimano, H, Tada, H, Takahashi, C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519198/
https://ncbi.nlm.nih.gov/pubmed/28650445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.51
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