Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures

Bacteriophages encode anti-CRISPR suppressors to counteract the CRISPR/Cas immunity of their bacterial hosts, thus facilitating their survival and replication. Previous studies have shown that two phage-encoded anti-CRISPR proteins, AcrF1 and AcrF2, suppress the type I-F CRISPR/Cas system of Pseudom...

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Vydáno v:Cell Res
Hlavní autoři: Peng, Ruchao, Xu, Ying, Zhu, Tengfei, Li, Ningning, Qi, Jianxun, Chai, Yan, Wu, Min, Zhang, Xinzheng, Shi, Yi, Wang, Peiyi, Wang, Jiawei, Gao, Ning, Gao, George Fu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518991/
https://ncbi.nlm.nih.gov/pubmed/28574055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.79
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