Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation

Chemotherapies are known often to induce severe gastrointestinal tract toxicity but the underlying mechanism remains unclear. This study considers the widely applied cytotoxic agent irinotecan (CPT-11) as a representative agent and demonstrates that treatment induces massive release of double-strand...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Lian, Qiaoshi, Xu, Jun, Yan, Shanshan, Huang, Min, Ding, Honghua, Sun, Xiaoyu, Bi, Aiwei, Ding, Jian, Sun, Bing, Geng, Meiyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518874/
https://ncbi.nlm.nih.gov/pubmed/28409562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.54
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