Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation

Many G protein-coupled receptors (GPCRs) are reported to be involved in the pathogenesis of multiple sclerosis (MS), and ~40% of all identified GPCRs rely on the Gαq/11 G protein family to stimulate inositol lipid signaling. However, the function of Gα subunits in MS pathogenesis is still unknown. I...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Lai, Weiming, Cai, Yingying, Zhou, Jinfeng, Chen, Shuai, Qin, Chaoyan, Yang, Cuixia, Liu, Junling, Xie, Xin, Du, Changsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518818/
https://ncbi.nlm.nih.gov/pubmed/28216651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2016.65
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