Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

It is well known that dendritic cells (DCs) play a pivotal role in triggering self-specific responses. Conversely, tolerogenic DCs (tolDCs), a specialized subset, induce tolerance and negatively regulate autoreactive responses. Tofacitinib, a Janus kinase inhibitor developed by Pfizer for treatment...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Zhou, Yan, Leng, Xiao, Luo, Shasha, Su, Zhiwei, Luo, Xingyan, Guo, Huijie, Mo, Chunfen, Zou, Qiang, Liu, Yang, Wang, Yantang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187469/
https://ncbi.nlm.nih.gov/pubmed/28070525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5021537
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