Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

Cryopreserved human hepatocytes were used to investigate the role of arylamine N-acetyltransferase 2 (NAT2; EC 2.3.1.5) polymorphism on the N-acetylation of isoniazid (INH). NAT2 genotype was determined by Taqman allelic discrimination assay and INH N-acetylation was measured by high performance liq...

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Vydáno v:Acta Pharm Sin B
Hlavní autoři: Doll, Mark A., Salazar-González, Raúl A., Bodduluri, Srineil, Hein, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518664/
https://ncbi.nlm.nih.gov/pubmed/28752039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.05.003
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